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Research Project

Clinical characteristics of AATD-related COPD patients diagnosed at age 65 and over and compared with younger counterparts

Principal Investigator:
Dilek Karadoğan
Center:
RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ EĞİTİM VE ARAŞTIRMA HASTANESİ
City/Country:
Rize (Turkey)
Start date:
November 2024
Status:
Ongoing
Contact E-mail:
dilek.karadogan@erdogan.edu.tr
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Introduction

It is important to compare the characteristics of COPD patients diagnosed in older ages with youngers to break the stereotype that AATD is a condition attributed to young COPD patients and to increase the rate of diagnosis at older ages. Therefore, cross-sectionally designed EARCO-aging study aims to evaluate the clinical characteristics as well as disease severity of COPD patients with AATD, by combined initial COPD assessment, according to their age at diagnosis by focusing on the group diagnosed at elderly.

 

Objectives

 

  • To compare the clinical characteristics and disease severity of elderly COPD patients in the EARCO database according to genotypes and diagnosis age groups.
  • To raise awareness in preventing underdiagnosis in elderly COPD patients

Inclusion criteria

Patients with at least COPD diagnosis with or without other comorbidities (pulmonary/extrapulmonary).

Brief summary

Although screening for AAT deficiency in all COPD patients has been recommended in guidelines for many years, clinicians concentrate mostly on younger COPD patients. The aim of this study was to evaluate patients with COPD in the EARCO database according to their age at diagnosis and to compare the demographic, clinical and functional characteristics of patients diagnosed at older ages with those diagnosed at younger ages. In addition, we aimed to examine whether older age at diagnosis is independently associated with disease severity.